Rph1 coordinates transcription of ribosomal protein genes and ribosomal RNAs to control cell growth under nutrient stress conditions.
Identifieur interne : 000052 ( Main/Exploration ); précédent : 000051; suivant : 000053Rph1 coordinates transcription of ribosomal protein genes and ribosomal RNAs to control cell growth under nutrient stress conditions.
Auteurs : Wen-Jie Shu [République populaire de Chine] ; Runfa Chen [République populaire de Chine] ; Zhao-Hong Yin [République populaire de Chine] ; Feng Li [République populaire de Chine] ; Heng Zhang [République populaire de Chine] ; Hai-Ning Du [République populaire de Chine]Source :
- Nucleic acids research [ 1362-4962 ] ; 2020.
Descripteurs français
- KwdFr :
- ARN ribosomique (génétique), Chromatine (génétique), Histone Demethylases (génétique), Phosphorylation (MeSH), Prolifération cellulaire (génétique), Protein kinases (génétique), Protéines de Saccharomyces cerevisiae (génétique), Protéines de répression (génétique), Protéines ribosomiques (génétique), Ribosomes (génétique), Ribosomes (métabolisme), Régulation de l'expression des gènes fongiques (génétique), Saccharomyces cerevisiae (génétique), Transcription génétique (MeSH), Transduction du signal (génétique).
- MESH :
- génétique : ARN ribosomique, Chromatine, Histone Demethylases, Prolifération cellulaire, Protein kinases, Protéines de Saccharomyces cerevisiae, Protéines de répression, Protéines ribosomiques, Ribosomes, Régulation de l'expression des gènes fongiques, Saccharomyces cerevisiae, Transduction du signal.
- métabolisme : Ribosomes.
- Phosphorylation, Transcription génétique.
English descriptors
- KwdEn :
- Cell Proliferation (genetics), Chromatin (genetics), Gene Expression Regulation, Fungal (genetics), Histone Demethylases (genetics), Phosphorylation (MeSH), Protein Kinases (genetics), RNA, Ribosomal (genetics), Repressor Proteins (genetics), Ribosomal Proteins (genetics), Ribosomes (genetics), Ribosomes (metabolism), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae Proteins (genetics), Signal Transduction (genetics), Transcription, Genetic (MeSH).
- MESH :
- chemical , genetics : Chromatin, Histone Demethylases, Protein Kinases, RNA, Ribosomal, Repressor Proteins, Ribosomal Proteins, Saccharomyces cerevisiae Proteins.
- genetics : Cell Proliferation, Gene Expression Regulation, Fungal, Ribosomes, Saccharomyces cerevisiae, Signal Transduction.
- metabolism : Ribosomes.
- Phosphorylation, Transcription, Genetic.
Abstract
Coordinated regulation of ribosomal RNA (rRNA) synthesis and ribosomal protein gene (RPG) transcription by eukaryotic RNA polymerases (RNAP) is a key requirement for growth control. Although evidence for balance between RNPI-dependent 35S rRNA production and RNAPII-mediated RPG transcription have been described, the molecular basis is still obscure. Here, we found that Rph1 modulates the transcription status of both rRNAs and RPGs in yeast. We show that Rph1 widely associates with RNAPI and RNAPII-transcribed genes. Deletion of RPH1 remarkably alleviates cell slow growth caused by TORC1 inhibition via derepression of rRNA and RPG transcription under nutrient stress conditions. Mechanistically, Rim15 kinase phosphorylates Rph1 upon rapamycin treatment. Phosphorylation-mimetic mutant of Rph1 exhibited more resistance to rapamycin treatment, decreased association with ribosome-related genes, and faster cell growth compared to the wild-type, indicating that Rph1 dissociation from chromatin ensures cell survival upon nutrient stress. Our results uncover the role of Rph1 in coordination of RNA polymerases-mediated transcription to control cell growth under nutrient stress conditions.
DOI: 10.1093/nar/gkaa558
PubMed: 32619236
PubMed Central: PMC7470948
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Life Sciences, Wuhan University, Wuhan, Hubei 430072 China.</nlm:affiliation><orgName type="university">Université de Wuhan</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author><author><name sortKey="Yin, Zhao Hong" sort="Yin, Zhao Hong" uniqKey="Yin Z" first="Zhao-Hong" last="Yin">Zhao-Hong Yin</name><affiliation wicri:level="4"><nlm:affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072 China.</nlm:affiliation><orgName type="university">Université de Wuhan</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author><author><name sortKey="Li, Feng" sort="Li, Feng" uniqKey="Li F" first="Feng" last="Li">Feng Li</name><affiliation wicri:level="4"><nlm:affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072 China.</nlm:affiliation><orgName type="university">Université de Wuhan</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhang, Heng" sort="Zhang, Heng" uniqKey="Zhang H" first="Heng" last="Zhang">Heng Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, 3888 Chenhua Road, Shanghai, 201062, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, 3888 Chenhua Road, Shanghai, 201062</wicri:regionArea><wicri:noRegion>201062</wicri:noRegion></affiliation></author><author><name sortKey="Du, Hai Ning" sort="Du, Hai Ning" uniqKey="Du H" first="Hai-Ning" last="Du">Hai-Ning Du</name><affiliation wicri:level="4"><nlm:affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072 China.</nlm:affiliation><orgName type="university">Université de Wuhan</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">Nucleic acids research</title><idno type="eISSN">1362-4962</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Proliferation (genetics)</term><term>Chromatin (genetics)</term><term>Gene Expression Regulation, Fungal (genetics)</term><term>Histone Demethylases (genetics)</term><term>Phosphorylation (MeSH)</term><term>Protein Kinases (genetics)</term><term>RNA, Ribosomal (genetics)</term><term>Repressor Proteins (genetics)</term><term>Ribosomal Proteins (genetics)</term><term>Ribosomes (genetics)</term><term>Ribosomes (metabolism)</term><term>Saccharomyces cerevisiae (genetics)</term><term>Saccharomyces cerevisiae Proteins (genetics)</term><term>Signal Transduction (genetics)</term><term>Transcription, Genetic (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN ribosomique (génétique)</term><term>Chromatine (génétique)</term><term>Histone Demethylases (génétique)</term><term>Phosphorylation (MeSH)</term><term>Prolifération cellulaire (génétique)</term><term>Protein kinases (génétique)</term><term>Protéines de Saccharomyces cerevisiae (génétique)</term><term>Protéines de répression (génétique)</term><term>Protéines ribosomiques (génétique)</term><term>Ribosomes (génétique)</term><term>Ribosomes (métabolisme)</term><term>Régulation de l'expression des gènes fongiques (génétique)</term><term>Saccharomyces cerevisiae (génétique)</term><term>Transcription génétique (MeSH)</term><term>Transduction du signal (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chromatin</term><term>Histone Demethylases</term><term>Protein Kinases</term><term>RNA, Ribosomal</term><term>Repressor Proteins</term><term>Ribosomal Proteins</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Proliferation</term><term>Gene Expression Regulation, Fungal</term><term>Ribosomes</term><term>Saccharomyces cerevisiae</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN ribosomique</term><term>Chromatine</term><term>Histone Demethylases</term><term>Prolifération cellulaire</term><term>Protein kinases</term><term>Protéines de Saccharomyces cerevisiae</term><term>Protéines de répression</term><term>Protéines ribosomiques</term><term>Ribosomes</term><term>Régulation de l'expression des gènes fongiques</term><term>Saccharomyces cerevisiae</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Ribosomes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Ribosomes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Phosphorylation</term><term>Transcription, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Phosphorylation</term><term>Transcription génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coordinated regulation of ribosomal RNA (rRNA) synthesis and ribosomal protein gene (RPG) transcription by eukaryotic RNA polymerases (RNAP) is a key requirement for growth control. Although evidence for balance between RNPI-dependent 35S rRNA production and RNAPII-mediated RPG transcription have been described, the molecular basis is still obscure. Here, we found that Rph1 modulates the transcription status of both rRNAs and RPGs in yeast. We show that Rph1 widely associates with RNAPI and RNAPII-transcribed genes. Deletion of RPH1 remarkably alleviates cell slow growth caused by TORC1 inhibition via derepression of rRNA and RPG transcription under nutrient stress conditions. Mechanistically, Rim15 kinase phosphorylates Rph1 upon rapamycin treatment. Phosphorylation-mimetic mutant of Rph1 exhibited more resistance to rapamycin treatment, decreased association with ribosome-related genes, and faster cell growth compared to the wild-type, indicating that Rph1 dissociation from chromatin ensures cell survival upon nutrient stress. Our results uncover the role of Rph1 in coordination of RNA polymerases-mediated transcription to control cell growth under nutrient stress conditions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32619236</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>15</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1362-4962</ISSN><JournalIssue CitedMedium="Internet"><Volume>48</Volume><Issue>15</Issue><PubDate><Year>2020</Year><Month>09</Month><Day>04</Day></PubDate></JournalIssue><Title>Nucleic acids research</Title><ISOAbbreviation>Nucleic Acids Res</ISOAbbreviation></Journal><ArticleTitle>Rph1 coordinates transcription of ribosomal protein genes and ribosomal RNAs to control cell growth under nutrient stress conditions.</ArticleTitle><Pagination><MedlinePgn>8360-8373</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/nar/gkaa558</ELocationID><Abstract><AbstractText>Coordinated regulation of ribosomal RNA (rRNA) synthesis and ribosomal protein gene (RPG) transcription by eukaryotic RNA polymerases (RNAP) is a key requirement for growth control. Although evidence for balance between RNPI-dependent 35S rRNA production and RNAPII-mediated RPG transcription have been described, the molecular basis is still obscure. Here, we found that Rph1 modulates the transcription status of both rRNAs and RPGs in yeast. We show that Rph1 widely associates with RNAPI and RNAPII-transcribed genes. Deletion of RPH1 remarkably alleviates cell slow growth caused by TORC1 inhibition via derepression of rRNA and RPG transcription under nutrient stress conditions. Mechanistically, Rim15 kinase phosphorylates Rph1 upon rapamycin treatment. Phosphorylation-mimetic mutant of Rph1 exhibited more resistance to rapamycin treatment, decreased association with ribosome-related genes, and faster cell growth compared to the wild-type, indicating that Rph1 dissociation from chromatin ensures cell survival upon nutrient stress. Our results uncover the role of Rph1 in coordination of RNA polymerases-mediated transcription to control cell growth under nutrient stress conditions.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shu</LastName><ForeName>Wen-Jie</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072 China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Runfa</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072 China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yin</LastName><ForeName>Zhao-Hong</ForeName><Initials>ZH</Initials><AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072 China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Feng</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072 China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Heng</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, 3888 Chenhua Road, Shanghai, 201062, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Hai-Ning</ForeName><Initials>HN</Initials><AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072 China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nucleic Acids Res</MedlineTA><NlmUniqueID>0411011</NlmUniqueID><ISSNLinking>0305-1048</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002843">Chromatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012335">RNA, Ribosomal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C400296">RPH1 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012097">Repressor Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012269">Ribosomal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.11.-</RegistryNumber><NameOfSubstance UI="D056466">Histone Demethylases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.-</RegistryNumber><NameOfSubstance UI="D011494">Protein Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber><NameOfSubstance UI="C410736">Rim15 protein, S cerevisiae</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002843" MajorTopicYN="N">Chromatin</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056466" MajorTopicYN="N">Histone Demethylases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011494" MajorTopicYN="N">Protein Kinases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012335" MajorTopicYN="N">RNA, Ribosomal</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012097" MajorTopicYN="N">Repressor Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012269" MajorTopicYN="N">Ribosomal Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012270" MajorTopicYN="N">Ribosomes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014158" MajorTopicYN="N">Transcription, Genetic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>12</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32619236</ArticleId><ArticleId IdType="pii">5867104</ArticleId><ArticleId 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IdType="pubmed">16469695</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement><orgName><li>Université de Wuhan</li></orgName></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Shu, Wen Jie" sort="Shu, Wen Jie" uniqKey="Shu W" first="Wen-Jie" last="Shu">Wen-Jie Shu</name></region><name sortKey="Chen, Runfa" sort="Chen, Runfa" uniqKey="Chen R" first="Runfa" last="Chen">Runfa Chen</name><name sortKey="Du, Hai Ning" sort="Du, Hai Ning" uniqKey="Du H" first="Hai-Ning" last="Du">Hai-Ning Du</name><name sortKey="Li, Feng" sort="Li, Feng" uniqKey="Li F" first="Feng" last="Li">Feng Li</name><name sortKey="Yin, Zhao Hong" sort="Yin, Zhao Hong" uniqKey="Yin Z" first="Zhao-Hong" last="Yin">Zhao-Hong Yin</name><name sortKey="Zhang, Heng" sort="Zhang, Heng" uniqKey="Zhang H" first="Heng" 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